University of Tabriz Journal of Zoonotic Diseases 2476-535X 10 2 2026 06 01 Retrospective evaluation of the determinants of compliance with the Egyptian mass drug administration programme for lymphatic filariasis 1161 1171 21703 10.22034/jzd.2026.21703 EN Mohammed Abdelmoneim Abdelham Alwehedy Department of Parasitology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt Ali Alsaid Ali Bohas Department of Parasitology, Faculty of Medicine, Benha University, Banhā, Egypt Atef Hussein Hussein Abdelhamid Department of Parasitology, Faculty of Medicine, Benha University, Banhā, Egypt Gehan Abdelrahman Rashed Department of Parasitology, Faculty of Medicine, Benha University, Banhā, Egypt Marwa Mohammed Ghallab Department of Parasitology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt Journal Article 2026 04 13 Lymphatic filariasis (LF) is a neglected tropical disease capable of causing significant morbidity, disability, and economic burden. Egypt launched the national LF elimination programme in 2000 via mass drug administration (MDA) and was recognized by WHO as having successfully achieved LF elimination in 2017. A cross-sectional study was conducted in a former Egyptian village included in the anti-LF MDA programme, to identify the determinants of individual compliance with MDA. From August 1 to December 31, 2022, all individuals who fulfilled the inclusion criteria were randomly selected from attendees of the Alkorain Endemic Diseases Centre. The study participants were interviewed to recall their MDA participation, and the data were then recorded in a structured questionnaire. Of the 75 individuals studied, 65.3% reported full compliance with MDA, and 57.7% of the non-compliant participants mentioned discontinued drug delivery as the reason for non-compliance. Full compliance was found to be significantly associated with age, education, and LF knowledge level. Moreover, univariate regression analysis showed that adults, males, government employees, those with academy/university education, and those with good LF knowledge had significantly higher odds of full compliance with all MDA rounds compared with children, females, students, those with elementary school education, and those with poor LF knowledge, respectively.  However, multivariate analysis indicated that educational level could be the most significant independent predictor of full compliance. Our study concluded that the individual's age, educational level, and knowledge level regarding LF can play a significant role in full compliance with anti-LF MDA programmes. https://jzd.tabrizu.ac.ir/article_21703_043db3fcb1987f659fe18d711209bac2.pdf