University of Tabriz Journal of Zoonotic Diseases 2476-535X 9 2 2025 04 01 The first serological detection and risk factors analysis of tick-borne Crimean-Congo hemorrhagic fever virus among sheep in Algeria 752 761 18672 10.22034/jzd.2024.18672 EN Sohaib El Ghazali Bennia Laboratory of Ecology of Terrestrial and Aquatic Systems (EcoSTAq), Department of Biology, Faculty of Science, Badji Mokhtar -Annaba University, Annaba, Algeria Zihad Bouslama Maamcha Laboratory of Ecology of Terrestrial and Aquatic Systems (EcoSTAq), Department of Biology, Faculty of Science, Badji Mokhtar -Annaba University, Annaba, Algeria Environmental Research Center, Annaba, Algeria Ghoulem Tiar Environmental Research Center, Annaba, Algeria Nadjet Frissou Laboratory L’IFORCE, Department of Operations Research, Faculty of Mathematics, USTHB, El-Alia, Algeria Environmental Research Center, Annaba, Algeria 0000-0002-4669-7371 Djilali Degui Department of Medicine, Faculty of Medicine and Pharmacy, University of Algiers 1, Algeria Fahem Rezoug Department of Clinical Medicine, Higher National Veterinary School, Algeria Haroune Bouzid Department of Clinical Medicine, Higher National Veterinary School, Algeria 0009-0005-0573-6388 Ali Lamara Department of Clinical Medicine, Higher National Veterinary School, Algeria/Laboratory for Animal Health and Production, Department of Clinical Medicine, Higher National Veterinary School, Algeria Journal Article 2024 08 18 The Crimean-Congo hemorrhagic fever (CCHF) is one of the zoonotic arboviral diseases transmitted by ticks. It is endemic in several parts of the world, including some African countries. This study was carried out to determine the possible circulation of the CCHF virus in Algeria. To this end, the study was carried out in several regions of northeastern Algeria, in which the sheep species was particularly targeted because of its importance in the epidemiology of the disease. Blood samples were collected from 276 sheep between September and November 2023, and the obtained sera were analyzed using an Enzyme-Linked Immunosorbent Assay (ELISA) to detect the presence of anti-CCHF virus antibodies. Region, age, sex, livestock farming type, and farm management system were analyzed as potential risk factors using a Chi-square (χ2) test and a multivariate regression analysis. The results revealed an overall prevalence rate of 39.13 %, suggesting the exposure of the sheep population to the CCHF virus, and hence the circulation of the virus throughout the study region. Region, age, and livestock farming type were determined to be potential risk factors associated with exposure to the CCHF virus. This is the first study to report the circulation of the CCHF virus among the Algerian sheep population. Further studies should be carried out to better understand CCHF epidemiology in the country.  https://jzd.tabrizu.ac.ir/article_18672_6bc17b9a9826dba93ca2f9fe1f5e770f.pdf